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KMID : 0357419940240010077
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Korean journal of Virology
1994 Volume.24 No. 1 p.77 ~ p.86
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Detection of Enteroviral RNA by PCR in Samples from Patients with Aseptic Meningitis in Korea,1993
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김문보
김기순/김창민/서순덕/윤재득/신학균.
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Abstract
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Aseptic meningitis is known that the sign of neurological diseases are present except paralysis even though the main sign and symptoms are fever and headache with nuchal rigidity of which is stiffness of the neck muscles due to meningeal
irritation
but
the damage is minor. Outbreakes are very common in young aged group during the warm season through the infection is spread mainly by the fecal-oral route from virus excretors to contacts and virus in pharyngeal secretion is also source of
infection.
Since sporadic clinical cases of aseptic meningitis has
reported in 1990, one of epidemic during the month of May, 1993 due to let enterovirus teams in NIH, Korea carried out seroepidemiological investigation against cases of aseptic meningitis which is a first time in Korea. Stool and CSF specimens
from 35
patients with aseptic meningitis were tested by neutralization test and PCR derived from the highly conserved 5'-noncoding enterovirus genomic region. We found a higher infection rate in the 1-9 years old group(68.5%) and in the male sex(68.5%).
ECHO
type 9 and 30 were isolated in fecal specimens and coxsackie type B was isolated in CSF. The PCR assay yielded positive results in 7 cases where enterovirus diagnosis were obtained by serological test.
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KEYWORD
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